U-Huisong Unikezwe Ukugunyazwa Kwelungelo Lobunikazi Lokusungulwa Okuhlobene ne-Yuxingcao Qinlan Heji

Ngomhla zi-3 kuNovemba 2023, i-Zhejiang Huisong Pharmaceuticals Co., Ltd. yanikezwa ukugunyazwa kwelungelo lobunikazi lokusungula indlela yokunquma ubuningi be-nucleosides e-Yuxingcao Qinlan Heji Intermediate. Ukusungulwa kudalula indlela yokunqunywa kwenani lama-nucleosides e-Yuxingcao Qinlan Heji Intermediate. Ama-nucleosides aphakathi ahlanganisa i-uridine ne-guanosine.
1) Lungiselela isixazululo sokuhlola nge-Yuxingcao Qinlan Heji Intermediate. Lungiselela isisombululo sereferensi usebenzisa inkomba ye-uridine standard kanye ne-guanosine reference standard.
2)Yenza ukuhlaziya kwe-chromatography ewuketshezi kusixazululo sereferensi nesixazululo sokuhlola, bese ulungiselela i-Waters Atlantis T3 njengekholomu ye-chromatographic; Sebenzisa amanzi njengesigaba A esihambayo kanye ne-acetonitrile njengesigaba B seselula ukuze uthole i-gradient elution.
3)Rekhoda i-chromatogram, ubala ngendawo ephakemeyo ukuze ihambisane nendlela evamile yangaphandle yokunquma okuqukethwe kwama-nucleoside esixazululweni sokuhlola.
Le ndlela, enezici zesikhathi esifushane sokuhlaziya, imfuneko yensimbi ephansi, inqubo elula, enomphumela onembile futhi onokwethenjelwa, ingagcwalisa igebe kubuchwepheshe obukhona ekulawuleni izinga lezithako ezisebenzayo zokwelapha kanye nabaphakathi.