I-Huisong inikwe uGunyaziso lwePatent eNxibelene neYuxingcao Qinlan Heji

Ngomhla wesi-3 kuNovemba ka-2023, i-Zhejiang Huisong Pharmaceuticals Co., Ltd. yanikwa imvume yokuyila yelungelo elilodwa lomenzi wechiza kwindlela yokumisela umyinge we-nucleosides eYuxingcao Qinlan Heji Intermediate. Ukuveliswa kubhengeza indlela yokumisela ubungakanani benucleosides eYuxingcao Qinlan Heji Intermediate. I-nucleosides ye-intermediate iquka i-uridine kunye ne-guanosine.
1)Lungisa isisombululo sovavanyo kunye neYuxingcao Qinlan Heji Intermediate. Lungiselela isisombululo sereferensi usebenzisa umgangatho wesalathiso we-uridine kunye nomgangatho wesalathiso we-guanosine.
2)Yenza uhlalutyo lwechromatography elulwelo kwisisombululo sereferensi kunye nesisombululo sovavanyo, kwaye ulungiselele i-Waters Atlantis T3 njengekholamu yechromatographic; Sebenzisa amanzi njengesigaba esishukumayo A kunye ne-acetonitrile njengesigaba esihambayo B sokukhanya kwethambeka.
3)Rekhoda ichromatogram, ubala ngommandla ophakamileyo ukuthobela indlela yomgangatho wangaphandle ukugqiba umxholo we-nucleosides kwisisombululo sovavanyo.
Le ndlela, eneempawu zexesha elifutshane lokuhlalutya, imfuneko yesixhobo esiphantsi, inkqubo elula, enesiphumo esichanekileyo nesithembekileyo, sinokuzalisa i-gap kwi-teknoloji ekhoyo ekulawuleni umgangatho wezithako ezisebenzayo zonyango kunye nabaphakathi.