Huisong e Fumuoe Tumello ea Patent ea Invention e Amanang le Yuxingcao Qinlan Heji

Ka la 3 Pulungoana 2023, Zhejiang Huisong Pharmaceuticals Co., Ltd. e ile ea fuoa tumello ea ho qapa bakeng sa mokhoa oa ho lekanya palo ea li-nucleosides ho Yuxingcao Qinlan Heji Intermediate. Moqapi ona o senola mokhoa oa ho fumana palo ea li-nucleoside ho Yuxingcao Qinlan Heji Intermediate. Li-nucleosides tsa bohareng li kenyelletsa uridine le guanosine.
1) Lokisetsa tharollo ea liteko ka Yuxingcao Qinlan Heji Intermediate. Lokisetsa tharollo ea litšupiso u sebelisa maemo a referense ea uridine le standard ea referense ea guanosine.
2) Etsa tlhahlobo ea chromatography ea metsi holim'a tharollo ea litšupiso le tharollo ea tlhahlobo, 'me u lokise Waters Atlantis T3 joalo ka kholomo ea chromatographic; Sebelisa metsi joalo ka karolo ea A e tsamaeang le acetonitrile joalo ka karolo ea B ea mobile bakeng sa ho hlakisoa ha gradient.
3) Rekota chromatogram, u bala ka sebaka se phahameng ho latela mokhoa o tloaelehileng oa kantle ho fumana hore na li-nucleosides li na le tharollo ea tlhahlobo.
Mokhoa ona, o nang le litšobotsi tsa nako e khutšoanyane ea ho hlahloba, tlhokahalo e tlaase ea lisebelisoa, mokhoa o bonolo, o nang le sephetho se nepahetseng le se ka tšeptjoang, o ka tlatsa lekhalo la theknoloji e teng ho laola boleng ba metsoako e sebetsang ea meriana le li-intermediates.