Ua Hāʻawi ʻia ʻo Huisong i ka Mana Mana Patent Invention e pili ana iā Yuxingcao Qinlan Heji

Ma Nowemapa 3, 2023, ua hāʻawi ʻia ʻo Zhejiang Huisong Pharmaceuticals Co., Ltd. i ka ʻae ʻia ʻana o ka patent no ka hoʻoholo ʻana i ke ʻano o nā nucleosides ma Yuxingcao Qinlan Heji Intermediate. Hōʻike ka mea hou i ke ʻano no ka hoʻoholo ʻana i ka nui o nā nucleosides ma Yuxingcao Qinlan Heji Intermediate. ʻO nā nucleosides o ka waena waena he uridine a me guanosine.
1) E hoʻomākaukau i ka hopena hoʻāʻo me Yuxingcao Qinlan Heji Intermediate. E hoʻomākaukau i ka hoʻonā kuhikuhi e hoʻohana ana i ka maʻamau kuhikuhi uridine a me ka maʻamau kuhikuhi guanosine.
2) Hana i ka hoʻoheheʻe chromatography wai ma ka hopena kuhikuhi a me ka hopena hoʻāʻo, a hoʻomākaukau i ka Waters Atlantis T3 ma ke kolamu chromatographic; E hoʻohana i ka wai e like me ka pae paʻa A a me ka acetonitrile ma ke ʻano paʻa paʻa B no ka elution gradient.
3) E hoʻopaʻa i ka chromatogram, e helu ana ma ka ʻāpana kiʻekiʻe e hoʻokō me ke ʻano maʻamau o waho e hoʻoholo ai i ka ʻike o nā nucleosides i ka hopena hoʻāʻo.
ʻO kēia ʻano, nona nā hiʻohiʻona o ka manawa loiloi pōkole, koi haʻahaʻa mea kani, kaʻina hana maʻalahi, me ka hopena pololei a hilinaʻi, hiki ke hoʻopiha i ka hakahaka o ka ʻenehana i kēia manawa i ka mana maikaʻi o nā mea hana lāʻau lapaʻau a me nā mea waena.